If you are looking for an ad layout that is about as ultra minimal as you can go, so that there are minimal distractions for your visitors, then this is a classic stripped back layout you need to try. Now available as a Quick Setup File in the members area.
Hi CTR Niche Classic
The large ad at the top gives maximum ad visibility.
The ad at the bottom of each post catches visitors who actually read your content and then look for somewhere else to go next.
The HeatMap Theme Recent Posts Plus Widget on the right also encourages further reading, but is used without thumbnail images to limit distraction.